Article about Donor IVF

I found this article through following a blog which linked to another which had this posted on their site.  I found it interesting and explanatory of egg donation and other methods or ART where a donor is needed. 

Myths and Reality of the “Donation”
from the online booklet – OOCYTE DONATION, By Cara Birrittieri, Mary M. Fusillo, RN, BSN, MS, and Georgia Witkin, PhD

You probably learned the following in your high school biology class, but most of us need a review to dispel many of the myths around baby making and making a baby with a donated egg. 

To create an embryo that will grow into a healthy child, you need genetic material from two different gene pools. The combined genetic material instructs the developing fetus to become a boy or a girl, tall or short, have curly hair or straight, blue eyes or brown.

Myth number 1
Fifty percent of the genetic material is delivered by a sperm cell. Most men think their sperm is carrying their own characteristics. This is the first myth. Actually their sperm is carrying genetic material from their entire gene pool (parents, grandparents, aunts, uncles, etc.). If the particular sperm that delivered the genetic material for your baby is carrying DNA for characteristics expressed in the father or sperm donor, the baby may resemble him. If, however, that particular sperm is carrying certain characteristics from great uncle Harry for a little girl with curly blonde hair and blue eyes, his daughter may look nothing like him with his straight dark hair and brown eyes. It’s the luck of the draw. Each sperm cell carries an entirely different combination of genes from the man’s ancestors.

The same of course is true for eggs or ova. Any given egg can contain genes from any group of ancestors — those that resemble the woman donating the eggs or those ancestors who look nothing like her. That means the genetic material in a donor’s egg may give instructions for a child to develop with very different features than the egg donor herself. (This has important implications when choosing an egg donor, which is discussed later). Once the two sets of genes combine, another step determines which traits will actually arise in the developing fetus and child. When the genes come together they all interact, some turn on and some turn off, so in reality, there is no telling which gene will do the instructing, and who your child will act like, look like, or sound like.

Think of a family that you know. If each genetic contribution in a child were an exact duplicate of their parent’s genes, all the girls and all the boys in the family would be clones of one another. The fact is that each egg and sperm contains a different combination of genes, and each time they unite a unique individual is created. That is why within the same family there might be some tall children, or short, some brown hair, or blond, some looking like one parent, or some who look like neither. Indeed, the only exception to this rule is identical twins. Their genes are identical because a single embryo splits in two, duplicates and develops as two people with the same genetic makeup. Everyone else has his or her own genetic combination or code. This is also why genetic testing is so accurate.

Myth number 2
Now here’s the part that may surprise you. Although this medical procedure is called “ovum donation,” the recipient does not receive someone’s egg in her uterus. This belief is another myth. Once the genetic material from the sperm and the egg has melded, the work of the sperm and the egg is done. The combined material duplicates itself and two new cells are created. The material duplicates again, and now you have four new cells. They double and there are eight. Soon there will be a ball of new cells — the beginning of a new human being (an embryo). When a woman gets pregnant on her own, this duplication process begins in the fallopian tube. When a donor egg is used, it happens in the IVF laboratory and the embryo(s) are transferred to the recipient’s uterus when it is about the same size it would be coming from the fallopian tube. It is that ball of cells (embryo), not someone else’s egg, which hopefully implants into the recipient’s uterine wall and begins to grow into a fetus.

Myth number 3
Perhaps the greatest myth surrounds pregnancy. Many believe the uterus is simply an incubator. Nothing could be further from the truth. The most important aspect of all pregnancies — including egg donation pregnancies — is that as the fetus grows, every cell in the developing body is built out of the pregnant mother’s body. Tissue from her uterine lining will contribute to the formation of the placenta, which will link her and her new child. The fetus will use her body’s protein, and then she will replace it. The fetus uses her sugars, calcium, nitrates, and fluids, and she will replace them. So, if you think of your dream child as your dream house, the genes provide merely a basic blueprint, the biological mother takes care of all the materials and construction, from the foundation right on up to the light fixtures. So, although her husband’s aunt Sara or the donor’s grandfather may have genetically programmed the shape of a new baby’s earlobe, the earlobe itself is the pregnant woman’s “flesh and blood.” That means the earlobe, along with the baby herself, grew from the recipient’s body. That is why she is the child’s biological mother. That is why this child is her biological child.

Many recipients ask, “Is the baby actually my flesh and blood?” Not literally. No baby is really its mother’s flesh and blood because the truth is that every fetus builds its own flesh and its own blood. Still you might wonder, “If it was my own egg, wouldn’t the baby then have my blood?” No. The baby might inherit your blood type, but would still be making its own blood, just as it makes its own skin and hair texture, and nails and teeth. Besides, with or without egg donation, the baby might have inherited his or her blood type from the father’s gene pool. Think of it this way: every baby is a complete, self-contained, unique human being. You will meet this person when he or she is born. To try to sort out the genetic contributions at that point is like trying to break a cake down into flour, sugar, water, and yeast after it has been baked. It is now a cake, no longer separate ingredients.